Author

Margot E. Manning

Boston Children's HospitalORCID 0000-0002-2933-0789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Audrey Sporrij· 2 shared Eva Maria FastiD· 2 shared Leonard Ira ZoniD· 2 shared Song P. YangiD· 2 shared Avik Choudhuri· 1 shared Brejnev Muhizi MuhireiD· 1 shared David T. ScaddeniD· 1 shared Edroaldo Lummertz da RochaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersDevelopmental Biology

Audrey Sporrij

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2 papers

Recent·Most cited

Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes

Audrey Sporrij, Meera P. Prasad, Brejnev Muhizi Muhire, Eva Maria Fast, Margot E. Manning, Avik Choudhuri, Jodi D. Weiss, Michelle Koh, Song P. Yang, Robert E. Kingston, Michael Yevgeniy Tolstorukov, Hans C. Clevers, Leonard Ira Zon

The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.

bioRxiv · Sep 12, 2022 · PreprintDevelopmental Biology

Niche signals regulate continuous transcriptional states in hematopoietic stem cells

Eva Maria Fast, Audrey Sporrij, Margot E. Manning, Edroaldo Lummertz da Rocha, Song P. Yang, Yi Zhou, Jimin Guo, Ninib Baryawno, Nikolaos Barkas, David T. Scadden, Fernando D. Camargo, Leonard Ira Zon

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

eLife · Nov 17, 2021Peer-reviewedDevelopmental Biology