Robert E. Kingston

The paper shows PRC1 condensates exclude SWI/SNF from chromatin, and SWI/SNF-bound chromatin reduces PRC1 binding, indicating mutual antagonism between these complexes.

The paper shows that PRC1 subunit composition and chromatin interactions influence condensate formation and stability in cells.

The paper uses multiomic analysis of leukemic clones in a mouse model to identify growth regulators and validate their roles in AML.

The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.

This study shows CBX2 is required for spermatogonial differentiation and long-term maintenance of male germ cells through chromatin compaction and phase separation.

This study shows that lncRNA DIGIT and BRD3 form phase-separated condensates to regulate endoderm differentiation by interacting with H3K18ac regions.

The paper shows that H3K27me3 is not needed for early differentiation but is required to maintain differentiated cell identity.

This study shows that mesendoderm competence in differentiating human pluripotent stem cells can be modulated by genetic perturbations and tracked using a low-dimensional reaction coordinate.

The paper analyzes histone modifications in Drosophila neural stem cells and their progeny to understand lineage decisions and epigenetic regulation during CNS development.

This study shows that a domain in CBX2 is required for both phase separation of PRC1 and nucleosome compaction, linking these processes to developmental patterning.