Michael Yevgeniy Tolstorukov

Atomistic TCR-ligand interactions shape memory T-cell differentiation

The paper identifies how TCR-ligand interactions influence memory T-cell differentiation by analyzing clonotype-specific signaling and functional outcomes.

Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes

The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly

This study shows that Sonic hedgehog signaling from cortical neurons regulates astrocyte development and synaptic connectivity during cortical circuit formation.

Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production

This study shows PRDM16 regulates MGE progenitor proliferation and GABAergic interneuron production by repressing differentiation genes.