Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response
John Mach, Carina L. Blaker, Bryony L. Winters, Yo Otsu, Elizabeth Clarke, Heather Gwynn Allore, Brent Vander Wyk, Kevin Winardi, Roderick Peel, Charlie W Gregson, Neda Assareh, Michelle Kourieh, Sarah Nicole Hilmer
This study evaluates the effects of oxycodone prescribing and deprescribing in a mouse model of osteoarthritis, showing that polypharmacy worsens outcomes and sex differences exist in treatment response.
bioRxiv · Oct 22, 2025 · PreprintPharmacology & Toxicology