SIRPA suppresses integrin-dependent virus endocytosis
Zhonghao Yan, Kruthika Raman Iyer, Minghao Li, Kie‐Hoon Jung, Ciara T. Hu, Natalia Ansin, Nicolás Sarute, Brian B. Gowen, Susan R. Ross
This study shows SIRPA inhibits integrin-dependent virus endocytosis by blocking a signaling pathway involving SHP2, SFKs, FAK, and alpha-integrin, offering therapeutic targets for RNA viruses.
bioRxiv · Apr 18, 2026 · PreprintCell Biology