A. Sorana Morrissy

This paper introduces PRIME-VLP, a delivery strategy that enhances prime editing efficiency for genome engineering and high-throughput screening using eVLPs.

This study identifies microbiome-derived hydroxyphenyl propanoates (HPPs) that enhance antitumour immunity by boosting gasdermin D activity in myeloid cells, improving immune checkpoint therapy outcomes in mice and correlating with better responses in human melanoma patients.

XenoSignal assesses ligand-receptor interactions across species using AlphaFold3 predictions to improve understanding of tumor-microenvironment crosstalk in xenograft models.

spOT-NMF improves spatial transcriptomics deconvolution by using optimal transport, outperforming existing methods in accuracy and scalability across various resolutions and species.

mosaicMPI integrates multi-omics data across cohorts to reveal biological themes and enable rapid mapping of new datasets.

The paper investigates synapse-specific diversity of GluN2 subunits in spinal lamina I neurons and shows how they differentially tune depolarization events.

PoolHapX reconstructs microbial haplotypes by integrating genetic sharing and genomic sequencing, outperforming existing tools and revealing new insights into HIV evolution.