Author

Mingzhu Wen

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Naihe JingiD· 3 shared Xianfa YangiD· 3 shared Fengxiang Tan· 2 shared Jinsong LiiD· 2 shared Penglei Shen· 2 shared Rui SongiD· 2 shared Yingying CheniD· 2 shared Yonggao Fu· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Naihe JingORCID

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3 papers

Recent·Most cited

Spatiotemporal Regulatory Logics of Mouse Gastrulation

Xianfa Yang, Bingbing Xie, Penglei Shen, Yingying Chen, C.C. Li, Fengxiang Tan, Yumeng Yang, Yun Seok Yang, Rui Song, Panpan Mi, Zhiwen Liu, Mingzhu Wen, Patrick Tam, Shengbao Suo, Naihe Jing

This study constructs a spatiotemporal regulatory framework for mouse gastrulation using multi-omic data and reveals mechanisms of lineage commitment and symmetry breaking.

Nature Communications · Jan 12, 2026Peer-reviewedDevelopmental Biology

Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway

Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, , Xianfa Yang

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

Advanced Science · Jun 29, 2025Peer-reviewedDevelopmental Biology

Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal molecular lock with Cubn to ensure proper stem cell differentiation and mouse embryogenesis

Zhiwen Liu, Xin Wan, Jiehui Chen, Yongjian Ma, Yonggao Fu, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang, Dahai Zhu, Jinsong Li, Naihe Jing, Xianfa Yang

This study identifies lncRNA-Gm26793 as a key regulator of stem cell differentiation and mouse embryogenesis through an inter-chromosomal interaction with Cubn.

Cell Discovery · Jun 3, 2025Peer-reviewedDevelopmental Biology