Author

Penglei Shen

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:multiome· 1

Frequent Co-Authors

Fengxiang Tan· 2 shared Mingzhu Wen· 2 shared Naihe JingiD· 2 shared Rui SongiD· 2 shared Xianfa YangiD· 2 shared Yingying CheniD· 2 shared Bingbing Xie· 1 shared C.C. LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersDevelopmental Biology

Fengxiang Tan

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2 papers

Recent·Most cited

Spatiotemporal Regulatory Logics of Mouse Gastrulation

Xianfa Yang, Bingbing Xie, Penglei Shen, Yingying Chen, C.C. Li, Fengxiang Tan, Yumeng Yang, Yun Seok Yang, Rui Song, Panpan Mi, Zhiwen Liu, Mingzhu Wen, Patrick Tam, Shengbao Suo, Naihe Jing

This study constructs a spatiotemporal regulatory framework for mouse gastrulation using multi-omic data and reveals mechanisms of lineage commitment and symmetry breaking.

Nature Communications · Jan 12, 2026Peer-reviewedDevelopmental Biology

Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway

Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, , Xianfa Yang

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

Advanced Science · Jun 29, 2025Peer-reviewedDevelopmental Biology