Cancer BiologybioRxivPreprint
PSMD14 drives melanoma cell survival and MAPK inhibitor resistance through histone H2A deubiquitination
Michael Ohanna, Pierric Biber, Mira Kahil…·Marcel Deckert
This study identifies PSMD14 as a key driver of melanoma survival and resistance to MAPK inhibitors by deubiquitinating histone H2A, altering chromatin state and gene expression.