Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway
Margaux Lecacheur, Ilona Berestjuk, Alexandrine Carminati, Mira Rabbaa, Océane Bouvet, Serena Diazzi, Pierric Biber, Christopher Rovera, Marie Irondelle, Frédéric Larbret, Virginie Prod’homme, Christophe A. J. Girard, Marcel Deckert, Sophie Tartare‐Deckert
This study shows that ECM stiffness influences dedifferentiated melanoma cells via DDR1/2 and YAP, affecting their behavior and drug resistance.
Oncogenesis · Jun 13, 2026Peer-reviewedCancer Biology