USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
Pierric Biber, Alexandrine Carminati, Walaa Mohager, Mickaël Ohanna, Christophe A. J. Girard, Margaux Lecacheur, Mira Kahil, Océane Bouvet, Marie Irondelle, Stéphane Audebert, Mehdi Khaled, Sophie Tartare‐Deckert, Marcel Deckert
This study identifies USP9X as a mechanosensitive deubiquitinase that stabilizes YAP to enhance tumor cell invasiveness and drug resistance.
Cell Reports · Oct 1, 2025Peer-reviewedCancer Biology