Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer's Disease-related pathology
Antonios Dougalis, Polina A. Abushik, Anssi Pelkonen, Luca Giudice, Mireia Gómez‐Budia, Nataliia Novosolova, Nelli‐Noora Välimäki, Mohammad Rezaie, Dilyara Nurkhametova, Raisa Giniatullina, Anastasia Shakirzyanova, Akash Shivling Mali, Tuomas H. Rauramaa, Beth Stevens, Mikko Hiltunen, , Tarja Malm
This study examines how early Alzheimer's disease-related pathology affects synaptic transmission and morphology in human cortical neurons using biopsies from patients with idiopathic normal pressure hydrocephalus.
bioRxiv · Jan 7, 2025 · PreprintNeuroscience