Author

Antonios Dougalis

University of Eastern FinlandORCID 0000-0002-2139-1616Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Tarja MalmiD· 4 shared Anssi PelkoneniD· 3 shared Mireia Gómez‐BudiaiD· 3 shared Anastasia ShakirzyanovaiD· 2 shared Polina A. AbushikiD· 2 shared Šárka LehtoneniD· 2 shared Tuomas H. RauramaaiD· 2 shared Ville LeinoneniD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Tarja MalmORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microelectrode array scaled for recording human hippocampal slices

Anssi Pelkonen, Vera Lezhnyova, Tomi Ryynänen, Joose Kreutzer, Valeriia Sitnikova, Mireia Gómez‐Budia, Adriana Della Pietra, Antonios Dougalis, Jenni Kyyriäinen, Mastaneh Torkamani‐Azar, Henri Eronen, Tuomas H. Rauramaa, Arto Immonen, Ville Leinonen, Alejandra Sierra, , Tarja Malm

The paper develops a custom microelectrode array for recording extracellular action potentials and local field potentials from human hippocampal slices to study temporal lobe epilepsy.

Epilepsia Open · Mar 25, 2026Peer-reviewedNeuroscience

Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer's Disease-related pathology

Antonios Dougalis, Polina A. Abushik, Anssi Pelkonen, Luca Giudice, Mireia Gómez‐Budia, Nataliia Novosolova, Nelli‐Noora Välimäki, Mohammad Rezaie, Dilyara Nurkhametova, Raisa Giniatullina, Anastasia Shakirzyanova, Akash Shivling Mali, Tuomas H. Rauramaa, Beth Stevens, Mikko Hiltunen, , Tarja Malm

This study examines how early Alzheimer's disease-related pathology affects synaptic transmission and morphology in human cortical neurons using biopsies from patients with idiopathic normal pressure hydrocephalus.

bioRxiv · Jan 7, 2025 · PreprintNeuroscience

Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microglia

Sara Kälvälä, Polina A. Abushik, Antonios Dougalis, Tarja Malm, Anssi Pelkonen, Šárka Lehtonen

This paper develops a method to culture midbrain organoids with microglia and air-liquid interface to improve neuronal functionality and integration of microglia.

bioRxiv · Oct 10, 2023 · PreprintNeuroscience

Microglia orchestrate neuronal activity in brain organoids

Ilkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gómez‐Budia, Henna Konttinen, Sohvi Ohtonen, Mohammad Feroze Fazaludeen, Marja Koskuvi, Johanna Kuusisto, Damián Hernández, Alice Pébay, Jari Koıstınaho, Šárka Lehtonen, Paula Korhonen, Tarja Malm

This study shows that incorporating microglial progenitors into human brain organoids supports neuronal maturation and synaptic activity.

bioRxiv · Dec 8, 2020 · PreprintNeuroscience