Author

Tuomas H. Rauramaa

University of Eastern FinlandORCID 0000-0002-2250-327XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

Tarja MalmiD· 5 shared Ville LeinoneniD· 5 shared Anssi PelkoneniD· 3 shared Beth StevensiD· 3 shared Mikko HiltuneniD· 3 shared Mireia Gómez‐BudiaiD· 3 shared Adriana Della PietraiD· 2 shared Alejandra SierraiD· 2 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersNeuroscience

Tarja MalmORCID

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Author profile →

8 papers

Recent·Most cited

Microelectrode array scaled for recording human hippocampal slices

Anssi Pelkonen, Vera Lezhnyova, Tomi Ryynänen, Joose Kreutzer, Valeriia Sitnikova, Mireia Gómez‐Budia, Adriana Della Pietra, Antonios Dougalis, Jenni Kyyriäinen, Mastaneh Torkamani‐Azar, Henri Eronen, Tuomas H. Rauramaa, Arto Immonen, Ville Leinonen, Alejandra Sierra, , Tarja Malm

The paper develops a custom microelectrode array for recording extracellular action potentials and local field potentials from human hippocampal slices to study temporal lobe epilepsy.

Epilepsia Open · Mar 25, 2026Peer-reviewedNeuroscience

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab

Jenni Kyyriäinen, Adriana Della Pietra, Mastaneh Torkamani‐Azar, Mireia Gómez‐Budia, Polina A. Abushik, Nataliia Novosolova, Henri Eronen, Omar Narvaez, Ekaterina Paasonen, Vera Lezhnyova, Anssi Pelkonen, Liudmila Saveleva, Antti Huotarinen, Ilya N Belevich, Eija Jokitalo, , Alejandra Sierra

The paper develops a protocol to characterize epileptogenic tissue using multimodal data from surgical samples, aiming to improve diagnosis and treatment of drug-resistant epilepsy.

Epilepsia Open · Dec 5, 2025Peer-reviewedNeuroscience

Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimers disease

Hamilton Se‐Hwee Oh, Deniz Yagmur Urey, Linda Karlsson, Zeyu Zhu, Yuanyuan Shen, Amelia Farinas, Jigyasha Timsina, Michael R. Duggan, Jingsha Chen, Ian Hunter Guldner, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Ali, Yann Le Guen, , Tony Wyss‐Coray

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

Nature Medicine · Mar 31, 2025Peer-reviewedNeuroscience✦ In-depth digest

Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer's Disease-related pathology

Antonios Dougalis, Polina A. Abushik, Anssi Pelkonen, Luca Giudice, Mireia Gómez‐Budia, Nataliia Novosolova, Nelli‐Noora Välimäki, Mohammad Rezaie, Dilyara Nurkhametova, Raisa Giniatullina, Anastasia Shakirzyanova, Akash Shivling Mali, Tuomas H. Rauramaa, Beth Stevens, Mikko Hiltunen, , Tarja Malm

This study examines how early Alzheimer's disease-related pathology affects synaptic transmission and morphology in human cortical neurons using biopsies from patients with idiopathic normal pressure hydrocephalus.

bioRxiv · Jan 7, 2025 · PreprintNeuroscience

Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show impaired energy metabolism but no cell pathologies

Dorit B. Hoffmann, Ville E. Korhonen, Hannah Rostalski, Nadine Huber, Sami Heikkinen, Tomi Hietanen, Rebekka Wittrahm, Stina Leskelä, Päivi H. Hartikainen, Tuomas H. Rauramaa, Eino Solje, Anne M. Portaankorva, Mikko Hiltunen, Ville Leinonen, Annakaisa Haapasalo

bioRxiv · May 28, 2024 · PreprintNeuroscience

Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states

Vahid Gazestani, Tushar Kamath, Naeem M. Nadaf, S.J. Burris, Brendan Rooney, Antti Junkkari, Charles R. Vanderburg, Tuomas H. Rauramaa, Martine Therrien, Matthew Tegtmeyer, Sanna‐Kaisa Herukka, Abdulraouf Abdulraouf, Samuel E. Marsh, Tarja Malm, Mikko Hiltunen, , Evan Z. Macosko

The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.

bioRxiv · Jun 3, 2023 · PreprintGenomics

Alzheimer's disease alters astrocytic functions related to neuronal support andtranscellular internalization of mitochondria

Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid A. Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, , Katja M. Kanninen

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

bioRxiv · Sep 15, 2021 · PreprintNeuroscience

Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques

Teemu Natunen, Henna Martiskainen, Mikael Marttinen, Sami Gabbouj, Hennariikka Koivisto, Susanna Kemppainen, Satu Kaipainen, Mari Takalo, Helena Svobodová, Luukas Leppänen, Benjam Kemiläinen, Simo Ryhänen, Teemu Kuulasmaa, Eija Rahunen, Sisko Juutinen, , Mikko Hiltunen

This study shows that a diabetic phenotype in mice and humans reduces microglial response to β-amyloid plaques, linking T2D and AD pathologies.

Molecular Neurodegeneration · Nov 9, 2020Peer-reviewedNeuroscience