Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntingtons Disease Through Complement-Dependent Mechanisms
Daniel K. Wilton, Kevin J. Mastro, Molly D. Heller, Frederick W. Gergits, Carly Rose Willing, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Anika Y. Kim, Richard L. M. Faull, Suman Jayadev, Ted A. Yednock, X. William Yang, Beth Stevens
This study shows that microglia and complement proteins drive early synapse loss and cognitive deficits in Huntington's disease by eliminating corticostriatal synapses, and that targeting this pathway can prevent these effects.
bioRxiv · Dec 3, 2021 · PreprintNeuroscience