Author
University of California, Los AngelesORCID 0000-0003-1127-4261Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Peter Langfelder, Nan Wang, Lalini Ramanathan…·X. William Yang
The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.
Nan Wang, Shasha Zhang, Peter Langfelder…·X. William Yang
This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.
C.Y. Daniel Lee, Amberlene J. De La Rocha, Kellie Inouye…·X. William Yang
This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.
Daniel K. Wilton, Kevin J. Mastro, Molly D. Heller…·Beth Stevens
This study shows that microglia and complement proteins drive early synapse loss and cognitive deficits in Huntington's disease by eliminating corticostriatal synapses, and that targeting this pathway can prevent these effects.
Chuan‐Le Xiao, Song Zhu, Minghui He…·Guang‐Rong Yan
This study identifies widespread N6-methyladenine (6mA) modification in the human genome, links it to gene expression, and shows its role in cancer by demonstrating reduced 6mA levels in tumors.