Author

Anthony Daggett

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

X. William YangiD· 2 shared Xiaofeng GuiD· 2 shared Amberlene J. De La RochaiD· 1 shared Anika Y. KimiD· 1 shared Arnaud Frouin· 1 shared Beth StevensiD· 1 shared C.Y. Daniel LeeiD· 1 shared Carly Rose Willing· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

X. William YangORCID

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2 papers

Recent·Most cited

BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice

C.Y. Daniel Lee, Amberlene J. De La Rocha, Kellie Inouye, Peter Langfelder, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Zoe Pamonag, Raymond Vaca, Jeffrey Richman, Riki Kawaguchi, Fuying Gao, Huaxi Xu, X. William Yang

This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.

bioRxiv · Aug 3, 2023 · PreprintNeuroscience

Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntingtons Disease Through Complement-Dependent Mechanisms

Daniel K. Wilton, Kevin J. Mastro, Molly D. Heller, Frederick W. Gergits, Carly Rose Willing, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Anika Y. Kim, Richard L. M. Faull, Suman Jayadev, Ted A. Yednock, X. William Yang, Beth Stevens

This study shows that microglia and complement proteins drive early synapse loss and cognitive deficits in Huntington's disease by eliminating corticostriatal synapses, and that targeting this pathway can prevent these effects.

bioRxiv · Dec 3, 2021 · PreprintNeuroscience