Frederick W. Gergits

The paper investigates the role of CSMD1 in opposing the complement cascade in neural tissues and links its dysfunction to schizophrenia risk.

This study shows that microglia and complement proteins drive early synapse loss and cognitive deficits in Huntington's disease by eliminating corticostriatal synapses, and that targeting this pathway can prevent these effects.

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.