Author

Arnaud Frouin

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Beth StevensiD· 3 shared Daniel K. WiltoniD· 2 shared Frederick W. GergitsiD· 2 shared Alanna E. Carey· 1 shared Allie K. Muthukumar· 1 shared Allison R. Bialas· 1 shared Andrew David ThompsoniD· 1 shared Anika Y. KimiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Beth StevensORCID

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3 papers

Recent·Most cited

CUB and Sushi Multiple Domains 1 (CSMD1) opposes the complement cascade in neural tissues

Matthew L. Baum, Daniel K. Wilton, Rachel G. Fox, Alanna E. Carey, Yu-Han H. Hsu, Ruilong Hu, Henna Jäntti, Jaclyn B. Fahey, Allie K. Muthukumar, Nikkita Salla, William J. Crotty, Nicole Scott‐Hewitt, Elizabeth Bien, David A. Sabatini, Toby Black Lanser, , Beth Stevens

The paper investigates the role of CSMD1 in opposing the complement cascade in neural tissues and links its dysfunction to schizophrenia risk.

Brain Behavior and Immunity · Mar 27, 2024Peer-reviewedNeuroscience

Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntingtons Disease Through Complement-Dependent Mechanisms

Daniel K. Wilton, Kevin J. Mastro, Molly D. Heller, Frederick W. Gergits, Carly Rose Willing, Arnaud Frouin, Anthony Daggett, Xiaofeng Gu, Anika Y. Kim, Richard L. M. Faull, Suman Jayadev, Ted A. Yednock, X. William Yang, Beth Stevens

This study shows that microglia and complement proteins drive early synapse loss and cognitive deficits in Huntington's disease by eliminating corticostriatal synapses, and that targeting this pathway can prevent these effects.

bioRxiv · Dec 3, 2021 · PreprintNeuroscience

A new organotypic model of synaptic competition reveals activity-dependent localization of C1q

Ryuta Koyama, Yuwen Wu, Allison R. Bialas, Andrew David Thompson, Christina A. Welsh, Arnaud Frouin, Chinfei Chen, Beth Stevens

The paper develops an organotypic coculture model to study activity-dependent synaptic competition and shows C1q localizes to less active synapses.

bioRxiv · Mar 20, 2017 · PreprintNeuroscience