A Critical Role for Neutral Sphingomyelinase-2 in Doxorubicin-induced Cardiotoxicity
Samia Mohammed, Victoria Franzi, Yaping Jiang, Fabiola Noelia Velazquez, Monica E. Alexander, Folnetti A. Alvarez, Danielle Lambadis, Sam B Chiappone, Anne G. Ostermeyer‐Fay, Leiqing Zhang, Achraf A. Shamseddine, Daniel Canals, Ashley J. Snider, Richard Z. Lin, Yusuf Awni Hannun, Christopher J. Clarke
This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.
bioRxiv · Mar 20, 2025 · PreprintCell Biology