Daniel Canals

KPB82 potently and selectively inhibits ACER2 and protects tumor and primary cells from doxorubicin-induced cytotoxicity

This paper identifies KPB82 as a potent and selective ACER2 inhibitor that reduces doxorubicin-induced cytotoxicity in multiple cell types.

Acid Stress-induced plasma membrane ceramide arises from lysosome-plasma membrane fusion

The paper identifies a lysosome-to-plasma membrane pathway for stress-induced plasma membrane ceramide generation, showing lysosomal ceramide is transferred to the plasma membrane under acidic stress.

Dithionite quenching of NBD-labeled lipids reveals artificial lipid droplet purity and neutral lipid surface accessibility

Sphingolipid regulation by yeast Mdm1 supports adaptive remodeling of the methionine transporter Mup1

This study shows that yeast Mdm1 links sphingolipid homeostasis to Mup1 endocytic remodeling, improving amino acid homeostasis and lifespan under nutrient limitation.

Metabolic plasticity enables cancer adaptation to acidic tumor ecosystems

This study shows cancer cells adapt to acidic tumor environments through sphingolipid metabolic plasticity, revealing that targeting metabolic flexibility, not individual pathways, may be more effective.

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains

This paper identifies DDHD2 as a neutral lipid lipase and transacylase that remodels triglyceride acyl chains by transferring acyl groups between lipids.

A Critical Role for Neutral Sphingomyelinase-2 in Doxorubicin-induced Cardiotoxicity

This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.

Critical Evaluation of Sphingolipids Detection by MALDI-MSI

This study evaluates sphingolipid detection by MALDI-MSI, identifies optimal protocols, and reports artifacts from fragmentation in different ion modes.