Yusuf Awni Hannun

This paper identifies KPB82 as a potent and selective ACER2 inhibitor that reduces doxorubicin-induced cytotoxicity in multiple cell types.

The paper identifies a lysosome-to-plasma membrane pathway for stress-induced plasma membrane ceramide generation, showing lysosomal ceramide is transferred to the plasma membrane under acidic stress.

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

This study identifies PKCα as a critical regulator of drug-tolerant persister cells in NSCLC, showing its role in enabling survival and relapse after TKI treatment.

This study shows cancer cells adapt to acidic tumor environments through sphingolipid metabolic plasticity, revealing that targeting metabolic flexibility, not individual pathways, may be more effective.

This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.

This study evaluates sphingolipid detection by MALDI-MSI, identifies optimal protocols, and reports artifacts from fragmentation in different ion modes.

This study shows that targeting acid ceramidase reduces fibrosis in mouse models of NASH without worsening metabolic features.