Author

N. A. Caveney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

K. C. Garcia· 3 shared N. Tsutsumi· 3 shared C. R. Glassman· 2 shared K. M. Jude· 2 shared C. Y. Janda· 1 shared D. Waghray· 1 shared N. Wang· 1 shared R. Hannoush· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

K. C. Garcia

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3 papers

Recent·Most cited

Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism

N. A. Caveney, N. Tsutsumi, K. C. Garcia

This study presents the cryo-EM structure of GC-C with Hsp90 and Cdc37, revealing how membrane receptor guanylyl cyclases use kinase-like Hsp90 regulatory mechanisms and informing therapeutic development.

bioRxiv · Feb 14, 2023Biochemistry

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

N. Tsutsumi, S. Hwang, S. Hansen, D. Waghray, N. Wang, Y. Miao, C. R. Glassman, N. A. Caveney, K. M. Jude, C. Y. Janda, R. Hannoush, K. C. Garcia

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

bioRxiv · Oct 21, 2022Biophysics

Structure of the IL-27 quaternary receptor signaling complex

N. A. Caveney, C. R. Glassman, K. M. Jude, N. Tsutsumi, K. C. Garcia

The paper determines the structure of the IL-27 receptor signaling complex using cryo-EM, revealing a unique three-site assembly mechanism distinct from related cytokines.

bioRxiv · Mar 8, 2022Immunology