Author

N. A. Holmes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. I. Hutchings· 4 shared B. Wilkinson· 3 shared S. F. Worsley· 3 shared A. M. Daniels· 1 shared A. R. Williams· 1 shared C. Murrell· 1 shared D. Heine· 1 shared D. J. Martins· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersEvolutionary Biology

M. I. Hutchings

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling

S. Denecke, M. F. Malfara, K. R. Hodges, N. A. Holmes, A. R. Williams, J. H. Gallagher-Teske, J. M. Pascarella, A. M. Daniels, G. J. Sterk, R. Leurs, G. Ruthel, R. Hoang, M. L. Povelones, M. Povelones

This study investigates how adhesion triggers differentiation in Crithidia fasciculata, showing cAMP signaling is critical for attachment and involves reorganization of signaling components along the flagellum.

bioRxiv · Oct 6, 2022Microbiology

Characterisation of the symbionts in the Mediterranean fruitfly gut

M. Darrington, P. T. Leftwich, N. A. Holmes, L. A. Friend, N. V. E. Clarke, S. F. Worsley, J. T. Margaritopoulos, S. A. Hogenhout, M. I. Hutchings, T. Chapman

The paper characterizes the gut microbiome of the Mediterranean fruitfly, identifying Klebsiella oxytoca as a dominant symbiont with potential nutritional benefits to the host.

bioRxiv · Jun 9, 2021 · PreprintEvolutionary Biology

Competition-based screening secures the evolutionary stability of a defensive microbiome

S. F. Worsley, T. M. Innocent, N. A. Holmes, M. M. Al-Bassam, B. Wilkinson, J. C. Murrell, J. J. Boomsma, D. W. Yu, M. I. Hutchings

The paper shows that competition-based screening by Pseudonocardia symbionts maintains a stable defensive microbiome in Acromyrmex ants by eliminating non-antibiotic-producing microbes.

bioRxiv · Nov 24, 2020Evolutionary Biology

Streptomyces endophytes promote the growth of Arabidopsis thaliana

S. F. Worsley, J. T. Newitt, J. Rassbach, S. F. D. Batey, N. A. Holmes, C. Murrell, B. Wilkinson, M. I. Hutchings

This study isolates Streptomyces bacteria from Arabidopsis thaliana roots and finds some strains promote plant growth while others inhibit growth due to antifungal properties.

bioRxiv · May 15, 2020 · PreprintMicrobiology

In situ activation and heterologous production of a cryptic lantibiotic from a plant-ant derived Saccharopolyspora species

E. Vikeli, D. Widdick, S. F. Batey, D. Heine, N. A. Holmes, M. J. Bibb, D. J. Martins, N. E. Pierce, M. I. Hutchings, B. Wilkinson

This paper identifies and activates a cryptic lantibiotic gene cluster in a plant-ant associated Saccharopolyspora species, enabling the discovery of a novel antibiotic, kyamicin, and demonstrating a platform for heterologous production of lanthipeptides.

bioRxiv · Aug 13, 2019Microbiology