S. A. Hogenhout

Bimodular Architecture of Bacterial Effector SAP05 Drives Ubiquitin-Independent Targeted Protein Degradation

This paper reports the crystal structures of SAP05 complexes and reveals their bimodular architecture enabling ubiquitin-independent targeted protein degradation in eukaryotic cells.

Hybridisation has shaped a recent radiation of grass-feeding aphids

This study shows hybridisation has contributed to the diversity and evolutionary potential of grain aphids, revealing a complex history of hybrid lineages and introgression.

Interfering with plant developmental timing promotes susceptibility to insect vectors of a bacterial parasite

This study shows that a bacterial parasite's effector gene SAP05 alters plant development to enhance insect vector reproduction.

Novel effector recognition capacity engineered into a paired NLR complex

The paper demonstrates a strategy to engineer plant immune receptors to recognize pathogen effectors by linking effector-dependent degradation to receptor function, resulting in SAP05-dependent resistance in Arabidopsis.

Characterisation of the symbionts in the Mediterranean fruitfly gut

The paper characterizes the gut microbiome of the Mediterranean fruitfly, identifying Klebsiella oxytoca as a dominant symbiont with potential nutritional benefits to the host.

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

The paper identifies effectors from plant pathogens that specifically target subsets of NRC immune receptor proteins, revealing convergent strategies to counteract redundant nodes in the NLR network.

Herbivore-induced activation of viral phosphatase disarms plant antiviral immunities for pathogen transmission

This paper shows how Begomovirus uses a phosphatase to suppress plant immunity, enhancing virus transmission by herbivore vectors.

Protein interaction mapping reveals widespread targeting of development-related host transcription factors by phytoplasma effectors

The paper maps protein interactions between phytoplasma effectors and Arabidopsis transcription factors, revealing specific targeting of development-related factors and unique infection strategies.

Chemosensory proteins in the CSP4 clade evolved as plant immunity suppressors before two suborders of plant-feeding hemipteran insects diverged

Phytoplasma SAP11 effector destabilization of TCP transcription factors differentially impact development and defence of Arabidopsis versus maize

This paper shows that SAP11 effectors from different phytoplasmas differentially destabilize TCP transcription factors, leading to distinct developmental and defense outcomes in Arabidopsis and maize.

An immuno-suppressive aphid saliva protein is delivered into the cytosol of plant mesophyll cells during feeding.

The paper shows that an aphid effector protein enters the cytosol of plant mesophyll cells during feeding, while another remains in the extracellular sheath saliva.