Author

G. Ruthel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

B. Freedman· 2 shared J. Liang· 2 shared M. L. Povelones· 2 shared R. N. Harty· 2 shared A. M. Daniels· 1 shared A. R. Williams· 1 shared A. Raj· 1 shared A. T. Phan· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

B. Freedman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling

S. Denecke, M. F. Malfara, K. R. Hodges, N. A. Holmes, A. R. Williams, J. H. Gallagher-Teske, J. M. Pascarella, A. M. Daniels, G. J. Sterk, R. Leurs, G. Ruthel, R. Hoang, M. L. Povelones, M. Povelones

This study investigates how adhesion triggers differentiation in Crithidia fasciculata, showing cAMP signaling is critical for attachment and involves reorganization of signaling components along the flagellum.

bioRxiv · Oct 6, 2022Microbiology

WWOX-Mediated Degradation of AMOTp130 Negatively Affects Egress of Filovirus VP40 VLPs

J. Liang, G. Ruthel, B. Freedman, R. N. Harty

This study shows that WWOX interacts with and degrades AMOTp130, reducing its ability to support filovirus VP40 VLP egress.

bioRxiv · Nov 19, 2021Microbiology

Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress

J. Liang, G. Ruthel, C. Sagum, M. T. Bedford, S. Sidhu, M. Sudol, C. K. Jaladanki, H. Fan, B. Freedman, R. N. Harty

This study identifies WWOX as a host protein that interacts with viral PPxY motifs to inhibit virus egress, revealing a competitive interplay with angiomotin.

bioRxiv · Jan 26, 2021Microbiology

cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory

D. A. Christian, T. A. Adams, T. E. Smith, L. A. Shallberg, D. J. Theisen, A. T. Phan, M. Abraha, J. Perry, G. Ruthel, J. T. Clark, K. M. Murphy, R. M. Kedl, C. A. Hunter

This study shows that cDC1 in the omentum support T cell expansion and survival during Toxoplasma gondii infection, not T cell priming.

bioRxiv · Jul 21, 2020Immunology

The single mitochondrion of the kinetoplastid parasite Crithidia fasciculata is a dynamic network

J. DiMaio, G. Ruthel, J. Cannon, M. Malfara, M. L. Povelones

This study investigates mitochondrial dynamics in Crithidia fasciculata, finding that mitochondrial division occurs during G1 phase and involves dynamic remodeling processes.

bioRxiv · Sep 6, 2018Cell Biology

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

J. Xu, Y. Sun, Y. Li, G. Ruthel, S. R. Weiss, A. Raj, D. Beiting, C. B. Lopez

This study shows replication defective viral genomes (DVGs) protect certain cells from death and promote viral persistence by activating a TNF-mediated survival pathway during infection.

bioRxiv · Aug 17, 2017Microbiology