Author

P. T. Leftwich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Bioengineering· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Arabidopsis· 2 Organism:Drosophila· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. Chapman· 3 shared L. A. Friend· 2 shared L. Alphey· 2 shared M. A. E. Anderson· 2 shared A. Uglow· 1 shared B. Longdon· 1 shared C. J. Breuker· 1 shared D. J. Obbard· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersEvolutionary Biology

T. Chapman

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Author profile →

5 papers

Recent·Most cited

Optimizing CRE and PhiC31 mediated recombination in Aedes aegypti

L. Z. Carabajal Paladino, R. Wilson, P. Y. L. Tng, V. Dhokiya, E. Keen, P. Cuber, W. Larner, S. Rooney, M. Nicholls, A. Uglow, L. Williams, M. A. E. Anderson, S. Basu, P. T. Leftwich, L. Alphey

This paper improves genetic manipulation techniques in Aedes aegypti by introducing transgenic lines for Cre-mediated recombination and a plasmid-based PhiC31 integrase system for stable transgene integration.

bioRxiv · Jul 7, 2023 · PreprintBioengineering

A multiplexed, confinable CRISPR/Cas9 gene drive propagates in caged Aedes aegypti populations

M. A. E. Anderson, E. Gonzalez, M. P. Edgington, J. X. D. Ang, D.-K. Purusothaman, L. Shackleford, K. Nevard, S. A. N. Verkuijl, T. Harvey-Samuel, P. T. Leftwich, K. Esvelt, L. Alphey

The paper tests a CRISPR/Cas9 gene drive in caged Aedes aegypti populations, showing it increases from 50% to 89% carrier frequency despite fitness costs.

bioRxiv · Aug 12, 2022 · PreprintSynthetic Biology

Characterisation of the symbionts in the Mediterranean fruitfly gut

M. Darrington, P. T. Leftwich, N. A. Holmes, L. A. Friend, N. V. E. Clarke, S. F. Worsley, J. T. Margaritopoulos, S. A. Hogenhout, M. I. Hutchings, T. Chapman

The paper characterizes the gut microbiome of the Mediterranean fruitfly, identifying Klebsiella oxytoca as a dominant symbiont with potential nutritional benefits to the host.

bioRxiv · Jun 9, 2021 · PreprintEvolutionary Biology

Transmission efficiency drives host-microbe associations

P. T. Leftwich, M. Edgington, T. Chapman

The paper models how different transmission modes affect host-microbe associations and finds that mixed transmission modes are most effective.

bioRxiv · Jul 23, 2020Evolutionary Biology

Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts

B. Longdon, J. Day, N. Schulz, P. T. Leftwich, M. A. de Jong, C. J. Breuker, M. Gibbs, D. J. Obbard, L. Wilfert, S. C. Smith, J. E. McGonigle, T. M. Houslay, L. I. Wright, L. Livraghi, L. C. Evans, , F. M. Jiggins

The paper identifies vertically transmitted rhabdoviruses in three insect species and shows they spread rapidly through host populations with high maternal transmission rates.

bioRxiv · Oct 31, 2016Evolutionary Biology