Author

N. Altemose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:scRNA-seq· 2 Research Focus:batch correction / integration· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. M. Streets· 3 shared A. Lai· 2 shared J. A. White· 2 shared A. B. Pinkerton· 1 shared A. Gupta· 1 shared A. M. Cypess· 1 shared A. Maslan· 1 shared A. P. White· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBioengineering

A. M. Streets

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

J. Tang, N. E. Weiser, G. Wang, S. Chowdhry, E. J. Curtis, Y. Zhao, I. T.-L. Wong, G. K. Marinov, R. Li, P. Hanoian, E. Tse, R. Hansen, J. Plum, A. Steffy, S. Milutinovic, , H. Y. Chang

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

bioRxiv · Mar 29, 2024 · PreprintCancer Biology

Characterization of transcript enrichment and detection bias in single-nuclei RNA-seq for mapping of distinct human adipocyte lineages

A. Gupta, F. Shamsi, N. Altemose, G. F. Dorlhiac, A. M. Cypess, A. P. White, M. E. Patti, Y.-H. Tseng, A. M. Streets

This study compares snRNA-seq and scRNA-seq in adipose tissue, showing snRNA-seq can identify cell types but has transcript enrichment and detection biases that require normalization.

bioRxiv · Mar 24, 2021Bioengineering

μDamID: a microfluidic approach for imaging and sequencing protein-DNA interactions in single cells

N. Altemose, A. Maslan, A. Lai, J. A. White, A. M. Streets

The paper introduces μDamID, a microfluidic platform that combines imaging and sequencing to study protein-DNA interactions in single cells, revealing 3D chromatin organization and gene regulation patterns.

bioRxiv · Jul 18, 2019Bioengineering

On-ratio PDMS bonding for multilayer microfluidic device fabrication

A. Lai, N. Altemose, J. A. White, A. M. Streets

The paper demonstrates that on-ratio PDMS bonding is effective for multilayer soft lithography, avoiding the issues of off-ratio bonding.

bioRxiv · Oct 23, 2018Bioengineering