N. Arnberg

Alpha-defensin binding expands human adenovirus tropism

This paper shows that human adenoviruses can bind to cells via alpha-defensins instead of their usual receptors, expanding their tropism to non-susceptible cells.

Structural Insights into the Interaction Between Adenovirus C5 Hexon and Human Lactoferrin

This study presents cryo-EM structures of HAdV-5C hexon and its complex with human lactoferrin, revealing molecular interactions critical for viral entry.

Bile acids accumulate norovirus-like particles and enhance binding to and entry into human enteric epithelial cells

This study shows that hydrophobic bile acids enhance norovirus VLP attachment and entry into human duodenal cells by aggregating virions near the cell surface.

Efficient clathrin-mediated entry of enteric adenoviruses in human duodenal cells

This study identifies clathrin- and dynamin-dependent pathways for efficient enteric adenovirus entry in human duodenal cells, highlighting kinetic advantages over other cell types.

Human AdV-20-42-42, a promising novel adenoviral vector for gene therapy and vaccine product development

This paper describes the development of a novel adenoviral vector, HAdV-20-42-42, which shows promise for gene therapy and vaccination due to its low seroprevalence and effective transduction capabilities.

The structure of enteric human adenovirus 41 - a leading cause of diarrhoea in children

This study determines the structure of enteric HAdV-F41 using cryo-EM, revealing structural differences from non-enteric HAdVs that explain its tissue tropism and pathogenicity.