Author

N. Barkas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Scadden· 2 shared N. Baryawno· 2 shared N. Severe· 2 shared P. V. Kharchenko· 2 shared A. Gnirke· 1 shared A. W. Mohammad· 1 shared B. Choi· 1 shared C. Burns· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

D. Scadden

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Thymic mesenchymal niche cells drive T cell immune regeneration

K. Gustafsson, S. Isaev, K. A. Kooshesh, N. Baryawno, K. D. Kokkaliaris, N. Severe, T. Zhao, E. W. Scadden, J. A. Spencer, C. Burns, K. Akilan, N. Barkas, H. Gessessew, C. P. Lin, P. V. Kharchenko, D. Scadden

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

bioRxiv · Oct 12, 2022Immunology

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

P. Bachireddy, C. Ennis, V. Nguyen, K. Clement, S. H. Gohil, S. A. Shukla, J. Forman, N. Barkas, S. Freeman, N. Bavli, L. Elagina, I. Leshchiner, A. W. Mohammad, L. Z. Rassenti, T. J. Kipps, , C. J. Wu

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.

bioRxiv · Apr 9, 2020Cancer Biology

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

N. Baryawno, Y. Kfoury, N. Severe, S. Mei, K. U. Gustafsson, T. Hirz, T. Brouse, E. Scadden, B. Choi, N. Barkas, J. Shin, P. Saylor, D. Scadden, D. Sykes, P. Kharchenko

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology