Author

P. V. Kharchenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Research Focus:cell-cell communication· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

N. Baryawno· 4 shared S. Mei· 3 shared A. O. Subtelny· 2 shared C.-L. Wu· 2 shared D. B. Sykes· 2 shared D. T. Scadden· 2 shared N. Barkas· 2 shared P. J. Saylor· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

N. Baryawno

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Thymic mesenchymal niche cells drive T cell immune regeneration

K. Gustafsson, S. Isaev, K. A. Kooshesh, N. Baryawno, K. D. Kokkaliaris, N. Severe, T. Zhao, E. W. Scadden, J. A. Spencer, C. Burns, K. Akilan, N. Barkas, H. Gessessew, C. P. Lin, P. V. Kharchenko, D. Scadden

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

bioRxiv · Oct 12, 2022Immunology

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

A. M. Alchahin, S. Mei, I. Tsea, T. Hirz, Y. Kfoury, D. Dahl, C.-L. Wu, A. O. Subtelny, S. Wu, D. T. Scadden, J. H. Shin, P. J. Saylor, D. B. Sykes, P. V. Kharchenko, N. Baryawno

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

bioRxiv · Jun 28, 2022Cancer Biology

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

T. Hirz, S. Mei, H. Sarkar, Y. Kfoury, S. Wu, B. M. Verhoeven, A. O. Subtelny, D. V. Zlatev, M. W. Wszolek, K. Salari, E. Murray, F. Chen, E. Z. Macosko, C.-L. Wu, D. T. Scadden, , D. B. Sykes

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

bioRxiv · Mar 18, 2022 · PreprintCancer Biology

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

T. K. Olsen, J. Otte, S. Mei, P. Kameneva, A. Bjoerklund, E. Kryukov, Z. Hou, A. Johansson, E. Sundstroem, T. Martinsson, S. Fransson, J. I. Johnsen, P. Kogner, I. Adameyko, P. V. Kharchenko, N. Baryawno

The paper identifies a subpopulation of malignant Schwann cell precursor-like cells in neuroblastoma that connects adrenergic and mesenchymal tumor cells, suggesting intratumoral plasticity mechanisms.

bioRxiv · May 4, 2020 · PreprintCancer Biology

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

P. Bachireddy, C. Ennis, V. Nguyen, K. Clement, S. H. Gohil, S. A. Shukla, J. Forman, N. Barkas, S. Freeman, N. Bavli, L. Elagina, I. Leshchiner, A. W. Mohammad, L. Z. Rassenti, T. J. Kipps, , C. J. Wu

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.

bioRxiv · Apr 9, 2020Cancer Biology