Author

J. A. Spencer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:development & morphogenesis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2

Frequent Co-Authors

C. Burns· 3 shared N. Seyedhassantehrani· 3 shared N. Abbasizadeh· 2 shared A. Kumanogoh· 1 shared A. Murison· 1 shared A. Pradeep· 1 shared A. Scialdone· 1 shared B. Chicana· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

C. Burns

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intravital Two-Photon Microscopy of the Native Thymus

N. Seyedhassantehrani, C. S. Burns, R. Verrinder, V. Okafor, N. Abbasizadeh, J. A. Spencer

This study uses intravital two-photon microscopy to examine thymic vascular changes after sublethal irradiation, finding increased vessel diameter and barrier function.

bioRxiv · Apr 10, 2023 · PreprintBioengineering

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing

T. Itkin, S. Houghton, R. Schreiner, Y. Lin, C. Badwe, V. Voisin, A. Murison, N. Seyedhassantehrani, K. B. Kaufmann, L. Garcia-Prat, G. T. Booth, F. Geng, Y. Liu, J. M. Gomez-Salinero, J.-H. Shieh, , S. Rafii

The paper identifies Fli-1's role in regulating HSC activation during regenerative hematopoiesis by enabling niche signaling and functional recovery.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

Thymic mesenchymal niche cells drive T cell immune regeneration

K. Gustafsson, S. Isaev, K. A. Kooshesh, N. Baryawno, K. D. Kokkaliaris, N. Severe, T. Zhao, E. W. Scadden, J. A. Spencer, C. Burns, K. Akilan, N. Barkas, H. Gessessew, C. P. Lin, P. V. Kharchenko, D. Scadden

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

bioRxiv · Oct 12, 2022Immunology

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

D. Toghani, S. Zeng, E. Mahammadov, E. I. Crosse, N. Seyedhassantehrani, C. Burns, D. Gravano, S. Radtke, H.-P. Kiem, S. Rodriguez, N. Carlesso, A. Pradeep, N. K. Wilson, S. J. Kinston, B. Gottgens, , L. Silberstein

This study identifies Sema4A as a critical niche factor required for myeloid-biased HSC self-renewal and long-term persistence under stress.

bioRxiv · Jan 12, 2022 · PreprintCell Biology

Deletion of Vhl in Dmp1-expressing cells causes microenvironmental impairment of B cell lymphopoiesis

B. Chicana, N. Abbasizadeh, C. Burns, H. Taglinao, J. A. Spencer, J. O. Manilay

This study shows that deleting Vhl in Dmp1-expressing cells impairs the B cell microenvironment in bone marrow, leading to B cell developmental defects.

bioRxiv · Sep 10, 2021Immunology