Author

N. Begley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

D. W. Ray· 3 shared G. B. Kitchen· 3 shared A. S. Loudon· 2 shared J. E. Gibbs· 2 shared A. Hespe· 1 shared A. J. Fisher· 1 shared A. L. Hunter· 1 shared A. Loudon· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

D. W. Ray

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Circadian clock function does not require the histone methyltransferase MLL3

M. Baxter, T. Poolman, P. Cunningham, A. L. Hunter, M. Voronkov, G. B. Kitchen, L. Goosey, N. Begley, D. Kay, A. Hespe, R. Maidstone, A. Loudon, D. W. Ray

This study shows that MLL3 methyltransferase activity is not required for circadian oscillations in vivo or in vitro, but may influence circadian control of inflammation in a sexually dimorphic manner.

bioRxiv · Dec 10, 2021 · PreprintMolecular Biology

Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infection.

G. B. Kitchen, T. Hopwood, T. G. Ramamoorthy, P. Downton, N. Begley, T. Hussell, D. H. Dockrell, J. E. Gibbs, D. W. Ray, A. S. Loudon

This study shows EZH2 has divergent roles in macrophages and neutrophils, enhancing macrophage immunity but impairing neutrophil chemotaxis during pulmonary infection.

bioRxiv · Jul 24, 2020 · PreprintCell Biology

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

P. S. Cunningham, P. Meijer, A. Nazgiewicz, S. G. Anderson, L. A. Borthwick, J. Bagnall, G. B. Kitchen, M. Lodyga, N. Begley, R. V. Venkateswaran, R. Shah, P. F. Mercer, H. J. Durrington, N. C. Henderson, K. Piper-Hanley, , J. Blaikley

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

bioRxiv · Sep 25, 2019Cell Biology