Author

D. H. Dockrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1

Frequent Co-Authors

M. Mohasin· 2 shared S. J. Jenkins· 2 shared A. M. Condliffe· 1 shared A. M. Hoy· 1 shared A. S. Loudon· 1 shared A. S. Mirchandani· 1 shared B. J. McHugh· 1 shared B. Malissen· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

M. Mohasin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Chromium/cadmium plays a pivotal role to emerge amoxicillin resistant Staphylococcus aureus

T. N. Islam, F. S. Meem, R. Yasmin, M. B. Amin, T. Rahman, D. H. Dockrell, M. Mohasin

This study shows that chromium and cadmium exposure with low-dose amoxicillin increases amoxicillin resistance in Staphylococcus aureus by upregulating efflux pumps.

bioRxiv · Feb 28, 2023 · PreprintMicrobiology

Mitochondrial fission is increased in macrophages during mROS production in response to S. pneumoniae

M. Mohasin, K. Balbirnie-Cumming, E. Fisk, E. C. Prestwich, C. D. Russell, J. Marshall, C. Pridans, S. P. Allen, P. J. Shaw, K. J. De Vos, C. J. Hill, P. Bullough, A. M. Condliffe, T. J. Mitchell, H. M. Marriott, D. H. Dockrell

This study shows that mitochondrial fission in macrophages increases during mROS production in response to S. pneumoniae, linked to reduced oxidative phosphorylation and enhanced bacterial killing.

bioRxiv · Nov 16, 2021 · PreprintImmunology

Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.

M. E. Candela, D. J. P. Allsop, R. N. Carter, F. Semple, F. Kilanowski, S. Webb, D. Taggart, H. J. W. Mullan, B. J. McHugh, D. H. Dockrell, D. J. Davidson, J. E. Allen, S. J. Jenkins, N. M. Morton, J. R. Dorin

This paper shows HBD3 limits macrophage classical activation and promotes alternative activation via IL-4R, enabling a repair-conducive state.

bioRxiv · May 6, 2021 · PreprintImmunology

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

J. McCowan, P. M. Kirkwood, F. Fercoq, W. T'Jonck, C. M. Mawer, R. Cunningham, A. S. Mirchandani, A. M. Hoy, G.-R. Jones, C. G. Hansen, N. Hirani, S. J. Jenkins, S. Henri, B. Malissen, S. R. Walmsley, , C. C. Bain

This study identifies EGR2 as essential for the identity and function of alveolar macrophages in health and tissue repair.

bioRxiv · May 6, 2021Immunology

Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infection.

G. B. Kitchen, T. Hopwood, T. G. Ramamoorthy, P. Downton, N. Begley, T. Hussell, D. H. Dockrell, J. E. Gibbs, D. W. Ray, A. S. Loudon

This study shows EZH2 has divergent roles in macrophages and neutrophils, enhancing macrophage immunity but impairing neutrophil chemotaxis during pulmonary infection.

bioRxiv · Jul 24, 2020 · PreprintCell Biology