Author

J. E. Gibbs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

D. W. Ray· 3 shared A. S. Loudon· 2 shared D. A. Bechtold· 2 shared G. B. Kitchen· 2 shared N. Begley· 2 shared P. Downton· 2 shared A. J. Fisher· 1 shared A. Nazgiewicz· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

D. W. Ray

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

P. Downton, S. H. Dickson, D. W. Ray, D. A. Bechtold, J. E. Gibbs

This study shows that fibroblast-like synoviocytes' circadian clock influences daily inflammation rhythms in arthritis, with Bmal1 deletion reducing arthritis susceptibility but increasing MMP3 production.

bioRxiv · Apr 2, 2024Immunology

Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism

H. A. Penny, R. G. Domingues, M. Z. Krauss, F. Melo-Gonzalez, S. Dickson, J. Parkinson, M. Hurry, C. Purse, E. Jegham, C. Godinho-Silva, M. Rendas, H. Veiga-Fernandes, D. Bechtold, R. K. Grencis, K.-M. Toellner, , M. R. Hepworth

This study shows diurnal rhythms in intestinal IgA regulate oscillations in commensal microbiota abundance, promoting mutualism.

bioRxiv · Oct 11, 2021Immunology

Ezh2 restrains macrophage inflammatory responses, and is critical for neutrophil migration in response to pulmonary infection.

G. B. Kitchen, T. Hopwood, T. G. Ramamoorthy, P. Downton, N. Begley, T. Hussell, D. H. Dockrell, J. E. Gibbs, D. W. Ray, A. S. Loudon

This study shows EZH2 has divergent roles in macrophages and neutrophils, enhancing macrophage immunity but impairing neutrophil chemotaxis during pulmonary infection.

bioRxiv · Jul 24, 2020 · PreprintCell Biology

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

P. S. Cunningham, P. Meijer, A. Nazgiewicz, S. G. Anderson, L. A. Borthwick, J. Bagnall, G. B. Kitchen, M. Lodyga, N. Begley, R. V. Venkateswaran, R. Shah, P. F. Mercer, H. J. Durrington, N. C. Henderson, K. Piper-Hanley, , J. Blaikley

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

bioRxiv · Sep 25, 2019Cell Biology