D. M. Muzny

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

Intra- and Inter-host Evolution of Human Norovirus in Healthy Adults

The paper studies intra- and inter-host evolution of human norovirus in healthy adults using a capture-based sequencing approach, finding limited conserved immune pressure-driven evolution.

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

Primate phylogenomics uncovers multiple rapid radiations and ancient interspecific introgression

This study uses genome-wide data to resolve primate phylogenetic relationships, identifying multiple radiations and ancient introgression events.

Paternal age in rhesus macaques is positively associated with germline mutation accumulation but not with measures of offspring sociability

This study estimates the de novo mutation rate in rhesus macaques and finds it is lower than in humans, but paternal age still correlates with increased mutations. No association is found between paternal age and offspring sociability.

Human NK cell deficiency as a result of biallelic mutations in MCM10

This study identifies biallelic MCM10 mutations as a cause of human NK cell deficiency, showing impaired NK cell maturation and function in a patient with CMV susceptibility.

Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

This study identifies three molecular types of meningiomas that better predict recurrence than WHO grading and links aggressive tumors to loss of DREAM complex repression.

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.

MHC genotyping from rhesus macaque exome sequences

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.

Hemimetabolous genomes reveal molecular basis of termite eusociality

The paper compares genomes and transcriptomes of termites and cockroaches to identify molecular mechanisms underlying termite eusociality, finding parallels and differences with Hymenoptera.