M. Borowiak

Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

This study shows that allelic bias in GINS4 variants contributes to variable clinical and cellular phenotypes in NK cell deficiency.

Next Generation Opto-Jasplakinolides Enable Local Remodeling of Actin Networks

This paper introduces a new generation of optojasplakinolides with improved photoswitching properties for precise control of actin dynamics in live cells.

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta

The paper identifies SMER28 as a compound that inhibits PI3K p110 delta and disrupts receptor tyrosine kinase signaling, leading to autophagy induction and reduced cell growth.

NFIA regulates granule recruitment and exocytosis in the adult pancreas

This study identifies NFIA as a regulator of granule recruitment and exocytosis in pancreatic cells, showing its role in insulin and enzyme secretion and linking it to metabolic disorders.

Human NK cell deficiency as a result of biallelic mutations in MCM10

This study identifies biallelic MCM10 mutations as a cause of human NK cell deficiency, showing impaired NK cell maturation and function in a patient with CMV susceptibility.