S. Paust

A Low-Dose Triple Antibody Cocktail Against the Ectodomain of the Matrix Protein 2 of Influenza A Is A Universally Effective and Viral Escape Mutant Resistant Therapeutic Agent

This paper develops a low-dose triple antibody cocktail targeting the conserved M2e antigen of influenza A, showing universal efficacy and resistance to viral escape mutants in mouse models.

Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

This study shows that infusing hematopoietic stem and progenitor cells (HSPCs) into septic mice improves survival by increasing immunomodulatory cells, despite similar pathogen loads.

Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice

This study shows that chronic alcohol exposure in mice increases systemic IFN-γ and IL-17 responses in a cell and organ-specific manner.

NK cells and CTLs are required to clear solid tumor in a novel model of patient-derived-xenograft

This study develops a novel syngeneic immune system PDX model to show that NK cells and CTLs are required for effective immunotherapy against solid tumors.

Human NK cell deficiency as a result of biallelic mutations in MCM10

This study identifies biallelic MCM10 mutations as a cause of human NK cell deficiency, showing impaired NK cell maturation and function in a patient with CMV susceptibility.