Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth
M. Liu, P. Arvan, J. Sun, Y. Xiong, X. Li, L. Haataja, W. Chen, S. A. Mir, R. Madley, D. Larkin, A. Anjum, B. Dhayalan, N. K. Rege, N. D. Wickramasinghe, M. A. Weiss, , D. A. Ostrov
This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.
bioRxiv · Oct 1, 2019Cell Biology