Author

D. A. Ostrov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Anjum· 1 shared A. Chopra· 1 shared A. J. Keeley· 1 shared A. Sette· 1 shared B. B. Lindsey· 1 shared B. Dhayalan· 1 shared C. N. Mavian· 1 shared COVID-19 Genomics UK (COG-UK) consortium· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCell Biology

A. Anjum

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

S. Leary, S. Gaudieri, M. D. Parker, A. Chopra, I. James, S. Pakala, E. Alves, M. John, B. B. Lindsey, A. J. Keeley, S. L. Rowland-Jones, M. Swanson, D. A. Ostrov, J. L. Bubenik, S. Das, , S. Mallal

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

bioRxiv · Apr 10, 2020 · PreprintMicrobiology

Recombination and purifying selection preserves covariant movements of mosaic SARS-CoV-2 protein S

M. S. Tagliamonte, N. Adid, D. A. Ostrov, G. Chillemi, S. L. Kosakovsky Pond, M. Salemi, C. N. Mavian

The paper analyzes SARS-CoV-2 evolution and structure to show recombination and purifying selection shape the S glycoprotein's function and efficiency in human infection.

bioRxiv · Mar 30, 2020 · PreprintEvolutionary Biology

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth

M. Liu, P. Arvan, J. Sun, Y. Xiong, X. Li, L. Haataja, W. Chen, S. A. Mir, R. Madley, D. Larkin, A. Anjum, B. Dhayalan, N. K. Rege, N. D. Wickramasinghe, M. A. Weiss, , D. A. Ostrov

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

bioRxiv · Oct 1, 2019Cell Biology