Author

S. D. Karam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Pierce· 1 shared B. Sanford· 1 shared D. M. Cittelly· 1 shared D. N. Effiom· 1 shared D. R. Ormond· 1 shared D. Wang· 1 shared E. Danis· 1 shared E. Specht· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Pierce

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy

L. Menzel, H. Zhou, J. W. Baish, M. J. O'Melia, L. B. Darragh, E. Specht, D. N. Effiom, J. Czapla, P.-j. Lei, J. J. Rajotte, L. Liu, M. R. Nikmaneshi, M. S. Razavi, M. G. Vander Heiden, J. M. Ubellacker, , T. P. Padera

The paper shows that removing tumor-draining lymph nodes does not impair immune checkpoint blockade response, as distant lymph nodes compensate for the loss.

bioRxiv · Sep 19, 2023Cancer Biology

Short-term Topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis

M. J. Contreras-Zarate, K. L. Alvarez, J. A. Jaramillo-Gomez, Z. Littrell, N. Tsuji, D. R. Ormond, S. D. Karam, P. Kabos, D. M. Cittelly

This study shows that short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical breast cancer brain metastasis models without affecting tumor growth.

bioRxiv · Feb 14, 2023Cancer Biology

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

F. M. Walker, L. Martin Sobral, E. Danis, B. Sanford, I. Balakrishnan, D. Wang, A. Pierce, S. D. Karam, N. J. Serkova, N. K. Foreman, S. Venkataraman, R. Dowell, R. Vibhakar, N. A. Dahl

The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology