A. Huttenlocher

Staphylococcus aureus lipid factors modulate melanoma clustering and invasion in zebrafish

This study shows that S. aureus supernatant increases melanoma invasion in zebrafish, likely mediated by bacterial lipids.

Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B

This study shows that ARPC1B in both neutrophils and endothelial cells regulates neutrophil motility, with endothelial ARPC1B being sufficient to drive neutrophil behavior.

Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

Naive primary neutrophils play a dual role in the tumor microenvironment

This study investigates the dual role of naive primary neutrophils in the tumor microenvironment, showing they both restrict tumor invasion and hinder NK cell penetration through ROS and NETs.

Confinement by liquid-liquid interface replicates in vivo neutrophil deformations and elicits bleb based migration

This paper introduces a liquid-liquid interface system to model in vivo neutrophil migration, finding that neutrophils use bleb-based force generation to deform barriers under confining pressures.

PTP1B phosphatase puts a brake on iPSC-derived neutrophil motility and antimicrobial function

This study shows that deleting PTP1B phosphatase enhances iPSC-derived neutrophil motility, antimicrobial function, and response to fungal pathogens.

Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration

The paper shows thermal injury causes keratinocyte migration and ROS production, which affects sensory axon regeneration, while mechanical injury does not.

Light sheet autofluorescence lifetime imaging with a single photon avalanche diode array

This paper introduces a light sheet FLIM system using SPAD arrays for fast, label-free single-cell NAD(P)H autofluorescence imaging in live cells and organisms.

Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection

A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish

This paper identifies a novel lymphoid network in zebrafish that enables whole-body T cell surveillance without lymph nodes, supporting both collective migration and antigen search.

In vivo fluorescence lifetime imaging captures metabolic changes in macrophages during wound responses in zebrafish

This paper uses in vivo FLIM to track metabolic changes in macrophages during wound responses in zebrafish, showing dynamic shifts in NAD(P)H and FAD redox ratios.

Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans

This study characterizes two clinical isolates of A. nidulans, showing differences in growth, metabolism, stress response, and virulence compared to a reference strain.

Citrullination regulates wound responses and tissue regeneration in zebrafish

This study shows that Padi2-mediated citrullination is essential for wound response and tissue regeneration in zebrafish by promoting histone modification and cell proliferation in the notochord bead.

Cell type specific gene expression profiling reveals a role for the complement component C3A in neutrophil migration to tissue damage

This study identifies C3A's role in neutrophil migration to tissue damage using TRAP-seq in zebrafish and shows impaired responses in c3a.1-/- larvae.

DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma

This study shows that DNAJB1-PRKACA fusion induces liver inflammation in a zebrafish FLC model by increasing immune cell infiltration and promoting a pro-inflammatory microenvironment.

Imaging invasive fungal growth and inflammation in NADPH oxidase-deficient zebrafish

The paper uses zebrafish to study how neutrophil ROS affects fungal growth and inflammation during infection with Aspergillus nidulans, finding that ROS limits fungal growth and reduces inflammation in PHOX-deficient hosts.

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.