Author

N. P. HARMSTON

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Madan· 3 shared D. M. Virshup· 2 shared E. G. Petretto· 2 shared S. Patnaik· 2 shared A. Kaur· 1 shared D. Epstein· 1 shared D. Virshup· 1 shared D. W. Nes· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

B. Madan

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Author profile →

3 papers

Recent·Most cited

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling

B. Madan, S. R. Wadia, S. Patnaik, N. P. Harmston, E. J. Tan, I. B. Tan, D. W. Nes, E. G. Petretto, D. M. Virshup

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

bioRxiv · Dec 15, 2023Cancer Biology

WNT inhibition creates a BRCA-like state in Wnt-addicted cancer

A. Kaur, S. Sepramaniam, J. Y. S. Lim, S. Patnaik, N. P. HARMSTON, M. A. Lee, E. G. Petretto, D. Virshup, B. Madan

The paper shows that Wnt inhibition creates a BRCA-like state in Wnt-addicted cancers, enhancing sensitivity to DNA damage.

bioRxiv · Jun 17, 2020Cancer Biology

The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity

J. Yu, P. A. Bt Mohamed Yuso, P. Goh, N. P. HARMSTON, D. Epstein, D. M. Virshup, B. Madan

This study identifies RNF43 mutations that predict sensitivity to Wnt inhibitors by analyzing their functional impact in vitro and in vivo.

bioRxiv · Mar 25, 2020 · PreprintCancer Biology