Author

E. G. Petretto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Madan· 2 shared J. Guo· 2 shared N. P. Harmston· 2 shared S. Patnaik· 2 shared A. A. Hii· 1 shared A. Kaur· 1 shared A. Zhang· 1 shared B. Ng· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

B. Madan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

H. Chen, R. You, J. Guo, W. Zhou, G. Chew, N. Devapragash, J. Z. Loh, L. Gesualdo, Y. Li, Y. Jiang, E. L. S. Tan, S. Chen, P. Pontrelli, F. Pesce, J. Behmoaras, , E. G. Petretto

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

Journal of the American Society of Nephrology · Mar 19, 2024Peer-reviewedCell Biology

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling

B. Madan, S. R. Wadia, S. Patnaik, N. P. Harmston, E. J. Tan, I. B. Tan, D. W. Nes, E. G. Petretto, D. M. Virshup

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

bioRxiv · Dec 15, 2023Cancer Biology

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

B. Ng, K. Y. Huang, C. J. Pua, W.-W. Lim, F. Kuthubudeen, A. A. Hii, S. Viswanathan, E. G. Petretto, S. A. Cook

This study shows IL11 impairs AT2 cell differentiation into AT1 cells and blocks lung regeneration in mice and humans.

bioRxiv · Nov 11, 2022Immunology

PLURIPOTENT STEM CELL-DERIVED CARDIOVASCULAR PROGENITORS DIFFFERENTIATED ON LAMININ 221 REGENERATE AND IMPROVE FUNCTION OF INFARCTED SWINE HEARTS

L. Yap, L. Y. Chong, C. Tan, S. Adusumalli, M. Seow, J. Guo, Z. Cai, S. J. Loo, E. Lim, N. Lath, L. Ye, E. G. Petretto, K. Tryggvason

This paper differentiates pluripotent stem cells into cardiovascular progenitors on laminin 221 and shows improved heart function in infarcted pigs.

bioRxiv · Apr 29, 2021 · PreprintCell Biology

WNT inhibition creates a BRCA-like state in Wnt-addicted cancer

A. Kaur, S. Sepramaniam, J. Y. S. Lim, S. Patnaik, N. P. HARMSTON, M. A. Lee, E. G. Petretto, D. Virshup, B. Madan

The paper shows that Wnt inhibition creates a BRCA-like state in Wnt-addicted cancers, enhancing sensitivity to DNA damage.

bioRxiv · Jun 17, 2020Cancer Biology