J. A. Smith

Multiple Unfolded Protein Response pathways cooperate to link cytosolic dsDNA release to Stimulator of Interferon Gene (STING) activation

This study identifies multiple UPR pathways that cooperate to link cytosolic dsDNA release to STING activation and IFN-β induction in response to ER stress.

Combining in vivo and in vitro approaches to better understand host-pathogen interactions

This study combines in vivo and in vitro approaches to show that host nutrition primarily affects bacterial growth in a host-parasite system, rather than host immune responses.

Nutribloods: novel synthetic lepidopteran haemolymphs for understanding insect-microbe interactions in vitro

The paper introduces synthetic haemolymphs (nutribloods) to study how nutrient profiles affect microbial growth in insect-pathogen interactions.

Searching the Pinus taeda foliar mycobiome for emerging pathogens among brown spot needle blight and needlecast outbreaks in the Southeast United States

This study identifies fungi associated with recent needle disease outbreaks in loblolly pine, finding Lecanosticta acicola in western areas and multiple pathogens linked to symptom variation.

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

Electrobiocorrosion by Microbes without Outer-Surface Cytochromes

This study identifies which methanogens and acetogens can perform electrobiocorrosion without outer-surface cytochromes, showing multiple strategies for electron transfer to Fe0.

Detrimental Impact of a Type VI Secretion System on Direct Interspecies Electron Transfer

This study shows that the type VI secretion system in Geobacter metallireducens affects DIET by altering gene expression and electron transfer efficiency.

Methane production by Methanothrix thermoacetophila via direct interspecies electron transfer with Geobacter metallireducens

This study identifies electron transfer mechanisms in Methanothrix thermoacetophila during direct interspecies electron transfer with Geobacter metallireducens using transcriptomics.

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

The paper uses a CRISPR screen to identify TREX1 as a pro-viral host factor that modulates DNA sensing during influenza infection.

Heating tolerance of ectotherms is explained by temperature's non-linear influence on biological rates

The paper shows that ectotherms' heating tolerance is consistent across acclimation temperatures when accounting for temperature's non-linear effects on biological rates.

Assessing the utility of death assemblages as reference conditions in a common benthic index (M-AMBI) with simulations

The paper evaluates how death assemblages can serve as reference conditions in benthic indices like M-AMBI through simulations, finding they can replicate remediation decisions effectively under environmental change.

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

This paper describes a high-throughput screening method using human PBMCs to identify adjuvant candidates, resulting in a lead compound with in vivo adjuvanticity.

Different Routes for Direct Interspecies Electron Transfer with Diverse Electron-Accepting Partners

This study compares the transcriptomes of Geobacter metallireducens during DIET with different electron-accepting partners, showing varied gene expression and requirements for DIET.

Identification of microRNAs that stabilize p53 in HPV-positive cancer cells

The paper identifies miRNAs that stabilize p53 in HPV-positive cancer cells through high-throughput screening and validates their potential as therapeutics.

Cytochrome OmcS is not essential for long-range electron transport in Geobacter sulfurreducens strain KN400

This study shows that OmcS is not essential for long-range electron transport in G. sulfurreducens strain KN400, as its deletion does not impair Fe(III) oxide reduction or direct interspecies electron transfer.

Brucella suppress innate immunity by down-regulating STING expression in macrophages

This study shows Brucella suppresses STING expression via miR-24 to evade innate immunity and establish chronic infection.

Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-like condensates in muscle cells

This study shows that alternative splicing of FXR1 regulates its function in muscle development by controlling RNA-dependent condensates and disease-related mis-splicing.

mRNA structure determines specificity of a polyQ-driven phase separation

The paper shows that mRNA secondary structures determine RNA-RNA interactions that influence phase separation and compartment identity.