Author

S. A. Mortensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Wilmanns· 4 shared G. Chojnowski· 2 shared A. Bochel· 1 shared A. Crousilles· 1 shared A. Krüger· 1 shared C. Litz· 1 shared C. M. Jeffries· 1 shared C. Ritter· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

M. Wilmanns

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Author profile →

4 papers

Recent·Most cited

Amino acid substitutions hydrophilizing the core of titin domains cause dilated cardiomyopathy

I. Martinez-Martin, A. Crousilles, J. P. Ochoa, D. Velazquez-Carreras, S. A. Mortensen, E. Herrero-Galan, F. Dominguez, P. Garcia-Pavia, D. De Sancho, M. Wilmanns, J. Alegre-Cebollada

The paper identifies amino acid substitutions in titin domains that increase hydrophilicity and cause dilated cardiomyopathy by destabilizing the protein structure.

bioRxiv · Jun 2, 2023Biochemistry

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

A. Bochel, S. A. Mortensen, L. Seifert, F. E. Hengel, C. M. Jeffries, G. Chojnowski, O. Kretz, T. B. Huber, N. M. Tomas, M. Wilmanns

This study determines the structure of the N-terminal didomain d1_d2 of THSD7A, revealing a non-canonical thrombospondin repeat fold with unique structural features contributing to its antigenicity.

bioRxiv · May 3, 2023 · PreprintBiophysics

Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex

N. Pinotsis, A. Krüger, N. Tomas, S. D. Chatziefthymiou, C. Litz, S. A. Mortensen, M. Daffe, H. Marrakchi, G. Antranikian, M. Wilmanns

The paper identifies and characterizes a non-canonical long-chain monoacylglycerol lipase using a high-resolution structure of an enzyme-substrate complex.

bioRxiv · Apr 7, 2022Biochemistry

Structure of the mycobacterial ESX-5 Type VII Secretion System hexameric pore complex

K. S. H. Beckham, C. Ritter, G. Chojnowski, E. Mullapudi, M. Rettel, M. M. Savitski, S. A. Mortensen, J. Kosinski, M. Wilmanns

The paper presents a high-resolution cryo-EM structure of the ESX-5 Type VII secretion system hexameric pore complex, revealing its assembly and potential gating mechanisms.

bioRxiv · Nov 17, 2020Microbiology