Author

M. Wilmanns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:protein structure prediction· 5 Assay:cryo-EM· 3 Assay:structural biology· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. A. Mortensen· 4 shared G. Chojnowski· 2 shared H. Rohde· 2 shared K. S. H. Beckham· 2 shared A. Berkes· 1 shared A. Bochel· 1 shared A. Crousilles· 1 shared A. Fadel· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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4 shared papersBiochemistry

S. A. Mortensen

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Author profile →

10 papers

Recent·Most cited

Amino acid substitutions hydrophilizing the core of titin domains cause dilated cardiomyopathy

I. Martinez-Martin, A. Crousilles, J. P. Ochoa, D. Velazquez-Carreras, S. A. Mortensen, E. Herrero-Galan, F. Dominguez, P. Garcia-Pavia, D. De Sancho, M. Wilmanns, J. Alegre-Cebollada

The paper identifies amino acid substitutions in titin domains that increase hydrophilicity and cause dilated cardiomyopathy by destabilizing the protein structure.

bioRxiv · Jun 2, 2023Biochemistry

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

A. Bochel, S. A. Mortensen, L. Seifert, F. E. Hengel, C. M. Jeffries, G. Chojnowski, O. Kretz, T. B. Huber, N. M. Tomas, M. Wilmanns

This study determines the structure of the N-terminal didomain d1_d2 of THSD7A, revealing a non-canonical thrombospondin repeat fold with unique structural features contributing to its antigenicity.

bioRxiv · May 3, 2023 · PreprintBiophysics

Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography

P. Mehrabi, S. Sung, D. von Stetten, A. Prester, C. E. Hatton, S. Kleine-Doepke, A. Berkes, G. Gore, J.-P. Leimkohl, H. Schikora, M. Kollewe, H. Rohde, M. Wilmanns, F. Tellkamp, E. C. Schulz

The paper introduces a device called spitrobot that enables millisecond time-resolved crystallography by cryo-trapping reaction intermediates.

bioRxiv · Sep 20, 2022 · PreprintBiophysics

Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex

N. Pinotsis, A. Krüger, N. Tomas, S. D. Chatziefthymiou, C. Litz, S. A. Mortensen, M. Daffe, H. Marrakchi, G. Antranikian, M. Wilmanns

The paper identifies and characterizes a non-canonical long-chain monoacylglycerol lipase using a high-resolution structure of an enzyme-substrate complex.

bioRxiv · Apr 7, 2022Biochemistry

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

E. Yifrach, D. Holbrook-Smith, J. Burgi, A. Othman, M. Eisenstein, C. W. T. Van Roermund, W. Visser, A. Tirosh, C. Bibi, S. Galor, U. Weil, A. Fadel, Y. Peleg, H. Waterham, R. J. Wanders, , E. Zalckvar

The paper identifies new peroxisomal functions in yeast by expanding the organellar proteome and analyzing sub-organellar localization and metabolic roles.

bioRxiv · Dec 8, 2021Cell Biology

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus

L. Paulowski, K. S. H. Beckham, M. D. Johansen, L. Berneking, N. Van, Y. Degefu, S. Staack, F. Vasquez Sotomayor, L. Asar, H. Rohde, B. B. Aldridge, M. Aepfelbacher, A. Parret, M. Wilmanns, L. Kremer, , F. P. Maurer

This study develops a C25-modified rifamycin derivative, 5j, which resists enzymatic inactivation by ArrMab and shows potent antimicrobial activity against M. abscessus in vitro and in macrophages.

bioRxiv · Jul 12, 2021Microbiology

Structure of the mycobacterial ESX-5 Type VII Secretion System hexameric pore complex

K. S. H. Beckham, C. Ritter, G. Chojnowski, E. Mullapudi, M. Rettel, M. M. Savitski, S. A. Mortensen, J. Kosinski, M. Wilmanns

The paper presents a high-resolution cryo-EM structure of the ESX-5 Type VII secretion system hexameric pore complex, revealing its assembly and potential gating mechanisms.

bioRxiv · Nov 17, 2020Microbiology

Structure-based identification and functional characterization of an essential lipocalin in the malaria parasite Plasmodium falciparum

P.-C. Burda, T. Crosskey, K. Lauk, A. Zurborg, C. Söhnchen, B. Liffner, L. Wilcke, J. Strauss, C. Jeffries, D. I. Svergun, D. W. Wilson, M. Wilmanns, T.-W. Gilberger

This study identifies and characterizes PfLCN, a lipocalin in Plasmodium falciparum, showing its role in oxidative stress response and parasite survival.

bioRxiv · Feb 13, 2020Cell Biology

Structural variability of EspG chaperones from mycobacterial ESX-1, ESX-3 and ESX-5 type VII secretion systems

A. T. Tuukkanen, D. Freire, S. Chan, M. A. Arbing, R. W. Reed, T. J. Evans, G. Zenkeviciute, J. Kim, S. Kahng, M. R. Sawaya, C. T. Chaton, M. Wilmanns, D. Eisenberg, A. H. A. Parret, K. V. Korotkov

The paper reports crystal and SAXS structures of EspG chaperones from mycobacterial ESX systems, revealing structural variability and potential substrate binding modes.

bioRxiv · Oct 13, 2018Biochemistry

Iterative model-based density improvement yields better atomic structures from cryo-EM maps

A. J. Jakobi, M. Wilmanns, C. Sachse

The paper introduces an iterative method to improve cryo-EM density maps using an atomic reference, leading to better atomic models.

bioRxiv · Mar 29, 2017Biophysics