R. Moncada

Mechanical confinement governs phenotypic plasticity in melanoma

This study shows mechanical confinement drives phenotype switching in melanoma via chromatin remodeling mediated by HMGB2.

Aging and senescence-associated analysis of the aged kidney glomerulus highlights the role of mesangial cells in renal aging

The paper analyzes aging and senescence in kidney glomeruli using bulk and single-cell RNA sequencing, identifying mesangial cells as key contributors to age-related renal dysfunction.

The renal capsule, a vibrant and adaptive cell environment of the kidney in homeostasis and aging

This study characterizes the renal capsule's cellular composition and dynamics in health, aging, and disease, revealing its adaptive responses and age-related changes.

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

Spatially resolved transcriptomics reveals the architecture of the tumor/microenvironment interface

This study uses spatial transcriptomics to identify a conserved tumor-microenvironment interface in zebrafish and human melanoma characterized by cilia gene upregulation.

A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistance

The paper identifies a stress-like cancer cell state in melanoma that promotes tumorigenesis and drug resistance, validated across zebrafish and human models.

Integrating single-cell RNA-Seq with spatial transcriptomics in pancreatic ductal adenocarcinoma using multimodal intersection analysis

This study integrates single-cell RNA-Seq and spatial transcriptomics data from pancreatic cancer tissue to map cell type spatial distributions and infer tissue architecture.