Author

N. R. Latorraca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Approach:mechanistic / dynamical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Marqusee· 5 shared C. Habrian· 3 shared E. Y. Isacoff· 3 shared B. K. Kobilka· 2 shared E. Montabana· 2 shared H. Wang· 2 shared J. G. Pelton· 2 shared A. Koehl· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBiophysics

S. Marqusee

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Author profile →

5 papers

Recent·Most cited

Domain coupling in activation of a family C GPCR

N. R. Latorraca, S. Sabaat, C. Habrian, J. Bleier, C. Stanley, S. Marqusee, E. Y. Isacoff

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

bioRxiv · Feb 28, 2024Biophysics

Step-wise activation of a Family C GPCR

K. K. Kumar, H. Wang, C. Habrian, N. R. Latorraca, J. Xu, E. S. O'Brien, C. Zhang, E. Montabana, A. Koehl, S. Marqusee, E. Y. Isacoff, B. K. Kobilka

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

bioRxiv · Aug 29, 2023 · PreprintBiophysics

Negative allosteric modulation of the glucagon receptor by RAMP2

K. Krishna Kumar, E. O'Brien, C. Habrian, N. R. Latorraca, H. Wang, I. Tuneew, E. Montabana, S. Marqusee, D. Hilger, E. Y. Isacoff, J. M. Mathiesen, B. K. Kobilka

This study shows RAMP2 inhibits GCGR signaling by inducing conformational changes and disorder in the receptor's extracellular domain.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

A Saturation-Mutagenesis Analysis of the Interplay Between Stability and Activation in Ras

F. Hidalgo, L. M. Nocka, N. H. Shah, K. Gorday, N. R. Latorraca, P. Bandaru, S. Templeton, D. Lee, D. Karandur, J. G. Pelton, S. Marqusee, D. Wemmer, J. Kuriyan

This study shows that cancer hotspot mutations in Ras activate it regardless of stability, while non-hotspot mutations can be activating or deleterious depending on stability.

bioRxiv · Jan 6, 2022Biophysics

Mechanistic basis for ubiquitin modulation of a protein energy landscape

E. C. Carroll, N. R. Latorraca, J. M. Lindner, B. C. Maguire, J. G. Pelton, S. Marqusee

This study investigates how ubiquitination at different sites affects the energy landscape of a model protein, revealing distinct thermodynamic mechanisms for destabilization and protection.

bioRxiv · Dec 6, 2020Biophysics