Author

E. Y. Isacoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Habrian· 4 shared J. Bleier· 3 shared N. R. Latorraca· 3 shared S. Marqusee· 3 shared B. K. Kobilka· 2 shared C. Stanley· 2 shared E. Montabana· 2 shared H. Wang· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiophysics

C. Habrian

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Domain coupling in activation of a family C GPCR

N. R. Latorraca, S. Sabaat, C. Habrian, J. Bleier, C. Stanley, S. Marqusee, E. Y. Isacoff

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

bioRxiv · Feb 28, 2024Biophysics

Conformational basis of subtype-specific allosteric control of NMDA receptor gating

J. Bleier, P. Ribeiro Furtado de Mendonca, C. Habrian, C. Stanley, V. Vyklicky, E. Y. Isacoff

This study uses smFRET to analyze GluN1 conformational changes in NMDA receptors with different GluN2 subunits, revealing subtype-specific allosteric control mechanisms.

bioRxiv · Feb 10, 2024 · PreprintBiophysics

Development of covalent chemogenetic K2P channel activators

P. E. Deal, H. Lee, A. Mondal, M. Lolicato, P. R. Furtado de Mandonca, H. Black, X. El-Hilali, C. Bryant, E. Y. Isacoff, A. Renslo, D. L. Minor

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

bioRxiv · Oct 15, 2023Biophysics

Step-wise activation of a Family C GPCR

K. K. Kumar, H. Wang, C. Habrian, N. R. Latorraca, J. Xu, E. S. O'Brien, C. Zhang, E. Montabana, A. Koehl, S. Marqusee, E. Y. Isacoff, B. K. Kobilka

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

bioRxiv · Aug 29, 2023 · PreprintBiophysics

Negative allosteric modulation of the glucagon receptor by RAMP2

K. Krishna Kumar, E. O'Brien, C. Habrian, N. R. Latorraca, H. Wang, I. Tuneew, E. Montabana, S. Marqusee, D. Hilger, E. Y. Isacoff, J. M. Mathiesen, B. K. Kobilka

This study shows RAMP2 inhibits GCGR signaling by inducing conformational changes and disorder in the receptor's extracellular domain.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels

D. M. Kern, J. Bleier, S. Mukherjee, J. M. Hill, A. A. Kossiakoff, E. Y. Isacoff, S. G. Brohawn

This study determines the structure of LRRC8A:C channels and shows how lipid interactions regulate their gating and assembly.

bioRxiv · Jul 31, 2022Biophysics